After pancreatoduodenectomy – a complex operation to remove part of the pancreas and surrounding digestive tract – leakage where the pancreas is reconnected remains a major cause of complications and death. Researchers examined its mechanical behavior to help refine the models used to train surgeons for this procedure. Using compression and dynamic mechanical testing, they found that human pancreas was markedly stiffer than biological and commercially available synthetic substitutes, while hard samples were more than twice as stiff as soft samples in both fresh and frozen states. Further analysis revealed frequency-dependent differences in material response that the synthetic material was unable to reproduce. Defining these mechanical properties could help future training models better reflect real pancreatic tissue, potentially shortening the learning curve and improving outcomes after surgery. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Quantifying the Viscoelastic Properties of Pancreatic Tissue: A Comparative Study of Human, Biological and Engineered Hydrogel 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Kunal Joshi, Daniel M. Espino, Duncan E. T. Shepherd, Nasim Mahmoodi, Keith J. Roberts, Nikolaos Chatzizacharias, Ravi Marudanayagam, and Robert P. Sutcliffe @unibirmingham @eps_unibham @SchoolofEng_UoB @uhbtrust @UHB_HPB @liveRPancSurg 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Detecting meaningful changes in heart sounds can be technically demanding, and this challenge can limit effective cardiovascular disease monitoring. Researchers investigated how the design of flexible sensors could improve heart sound detection, focusing on four performance-related factors: area, aspect ratio, thickness, and encapsulation. Simulations and mechanical testing showed that output generally improved with greater sensor area and polydimethylsiloxane encapsulation, although testing did not always match simulations when researchers varied sensor thickness and aspect ratio. Guided by these findings, the team optimized a flexible sensor and evaluated its performance using simulated heart sounds, where it produced approximately 1.79 times the output voltage of a commercial sensor. Greater clarity around the influence of key design factors on sensor performance could support more sensitive wearable cardiac monitoring, giving clinicians richer acoustic information to assess heart abnormalities and follow their progression over time. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Correlation Between Structural Parameters and Piezoelectric Performance of PVDF Heart Sound Sensors 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Ke Wang, Ruiqiang Zheng, Rongguo Yan, Shoucheng Chen, and Wenjing Du 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

The way gut bacteria process bile salts may influence colorectal cancer, but exactly how these microbial activities affect intestinal tissue is not well understood. Exploring this relationship, researchers developed a controlled co-culture platform combining healthy and tumor-derived colon organoids with an engineered Escherichia coli strain that produces bile salt hydrolase. The engineered bacteria preferentially colonized tumor organoids and restored farnesoid X receptor signaling in healthy organoids, while tumor organoids resisted this effect. The researchers also found that bile salt exposure and bacterial colonization had opposing effects on Hspg2, a gene associated with bacterial attachment to the intestinal surface. These findings suggest that cancerous tissue may respond differently to bacteria-driven changes in bile salts – a distinction that could be leveraged in designing more selective therapies. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Bile Salts and Bacterial Bile Salt Hydrolase Activity Influence Escherichia coli Colonization and FXR Signaling in Colorectal Cancer Organoids 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Ishita Dasgupta, Arianna Brevi, Yixiao Ma, Durga Prasad Rangineni, Miriam Duran, Amir Zarrinpar, and Abhinav Bhushan @illinoistech @UCSanDiego @Zarrinparlab 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

As AI methods for medical imaging multiply, determining which approaches are best suited to specific clinical applications is becoming more complex. To help navigate these choices, three engineers wrote a literature review surveying learning-based medical image classification, emphasizing advances most relevant to clinical translation – including foundation models, vision–language models, hybrid architectures, self-supervised pretraining, federated learning, and efficient deployment. The authors examine how differences among imaging modalities, available data, and clinical workflows influence which models are appropriate for a given application. They also assess obstacles that can undermine performance outside controlled research settings, including bias arising from limited data diversity and the difficulty of detecting rare conditions. By connecting technical advances with the realities of clinical use, this review could help shift the focus from what AI models can achieve to where they can deliver meaningful value. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Overview of State-of-the-Art Learning-Based Classification Methods in Medical Imaging 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Nafiseh Ghaffar Nia, Rayyan Manwar, and Kamran Avanaki @thisisUIC 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Restoring hand function after injury or illness can require carefully controlled resistance during rehabilitation – something conventional splints struggle to provide. Engineers developed a dynamic hand splint that replaces traditional elastic components with soft pneumatic actuators designed to provide controllable resistance during finger flexion. The prototype uses an actuator mounted on a forearm brace and connected to a finger through a tendon, while an onboard load cell monitors force during movement. Psychophysical testing showed that users could reliably perceive changes in resistance and that increasing actuator pressure reduced the average force on a fully flexed finger from approximately 5.2 newtons to as little as 0.7 newtons. Actively controlled force could allow hand rehabilitation exercises to respond to changing needs, allowing clinicians to adjust therapeutic demands as recovery progresses. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Hand Rehabilitation Dynamic Splint with Variable Force via Pneumatic Artificial Muscle Actuators 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Valentina Potnik, Gabriele Frediani, Mattia Dimitri, and Federico Carpi @UNI_FIRENZE 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Determining how the brain maintains stable blood flow could be key to improving treatment for cerebrovascular disorders – a goal that requires better ways to measure this complex regulatory process. With this in mind, researchers developed a numerical algorithm that quantifies how changes in arterial pressure, oxygen, and carbon dioxide affect the brain’s regulation of cerebral blood flow. They integrated the algorithm with a personalized multidimensional model to account for individual-specific effects. Across two independent datasets, the model reliably reproduced observed physiological responses and maintained strong agreement with experimental measurements under varying conditions. By capturing how an individual brain responds to changing physiological conditions, this framework could ultimately help clinicians determine when and how to intervene before impaired blood flow causes further harm. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Enhancing Understanding and Clinical Applications of Cerebral Autoregulation: A Novel Integrated Numerical Framework 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Qi Zhang, Meng-di Yang, Xuan-hao Xu, Xiu-li Xu, Shuai Tian, and Li-ling Hao @SYSUworld 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Concussions can occur even when conventional measures of head acceleration suggest an impact should pose relatively little risk. A letter to the editor offers one possible explanation, proposing that short-duration impacts may cause high-frequency vibrations and flexing of the skull that contribute to concussion-like signs and symptoms. Drawing on prior biomechanical research, the author suggests that these responses may transfer mechanical energy into intracranial tissues in ways not captured by traditional measures of rigid-body motion. The hypothesis could account for why baseball catchers experience concussions from foul tips despite substantially lower accelerations than those typically associated with concussions in football. To determine whether this proposed mechanism contributes to injury, the author calls for further testing that could reveal overlooked sources of risk and inform how head protection is evaluated and designed for short-duration impacts. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗟𝗲𝘁𝘁𝗲𝗿: A Vibration-Based Concussion Mechanism 𝗔𝘂𝘁𝗵𝗼𝗿: @strowson @virginia_tech @VTEngineering @BEAMvt 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Calcium deposits in the knee may be associated with osteoarthritis progression, but their involvement in joint degeneration remains difficult to assess in the body. A key obstacle is distinguishing different types of calcification in the body, and researchers sought to address it by evaluating whether photon-counting dual-energy CT could differentiate basic calcium phosphate from calcium pyrophosphate deposits in meniscus samples. Using Raman spectroscopy as a reference, they analyzed 36 samples containing only one calcification type and found differences in dual-energy measurements between the two minerals. The differences suggest that their distinct compositions may produce measurable imaging signatures that could enable the calcification types to be distinguished. CT-based differentiation of these deposits could provide a noninvasive way to assess whether therapies targeting mineral deposition are altering disease progression, potentially informing the development of disease-modifying treatments for osteoarthritis. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Characterizing Meniscal Calcifications with Photon Counting-Based Dual-Energy Computed Tomography 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Eeva Alina Nevanranta, Ville-Pauli Karjalainen, Mikael Brix, Iida Hellberg, Aleksandra Turkiewicz, Bijay Shakya, Patrik Önnerfjord, Sampo Ylisiurua, Amanda Sjögren, Khaled Elkhouly, Velocity Hughes, Jon Tjörnstrand, Simo Saarakkala, Martin Englund, and Mikko A. J. Finnilä @UniOulu @HST_OY @OYS_sairaala @lunduniversity @ssaarakk @dr_englund 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Changes in how the brain regulates blood flow and oxygen may contribute to cognitive decline, but detecting these vascular abnormalities at an early stage remains difficult. Taking aim at this problem, researchers compared how the brain responded to shifts in oxygen and carbon dioxide in healthy adults and those with mild cognitive impairment. Participants underwent controlled changes in inhaled oxygen and carbon dioxide while cerebral oxygenation, blood pressure, and other physiological signals were measured and dynamic modeling was used to characterize their responses. Compared with healthy controls, the mild cognitive impairment group showed altered blood pressure and carbon dioxide responses consistent with impaired vascular and reflex control and possible disruption of neurovascular coupling. The physiological differences observed in this study could inform biomarkers for detecting cerebrovascular dysfunction sooner, helping identify individuals who may benefit from closer monitoring or targeted strategies to preserve cognitive function. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: PRBS Gas Challenges Reveal Impaired Chemoreflex and Cholinergic Dynamics in MCI 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Suhaib Hashem, Stanley Yamashiro, Elizabeth Joe, Helena Chui, and Vasilis Marmarelis @USC @USCViterbi @USCBME @KeckSchool_USC 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Distinguishing predatory journals from legitimate publications can be difficult and may put researchers at risk of submitting their work to deceptive outlets. In a letter to the editor, the author outlines warning signs of questionable publications, from fabricated editorial credentials and indexing claims to hidden fees and promises of rapid or guaranteed acceptance. He notes that biomedical engineering researchers may be particularly vulnerable because of the field’s interdisciplinary nature, publication pressures, and increasing use of AI tools in manuscript preparation. Recommended safeguards include verifying journal claims through official sources, consulting trusted colleagues or mentors, and prioritizing publication quality over quantity – measures that can help researchers avoid deceptive publications and protect academic integrity and professional reputation. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗟𝗲𝘁𝘁𝗲𝗿: Identifying Predatory Journals: A Practical Guide for Researchers 𝗔𝘂𝘁𝗵𝗼𝗿: Louie Giray @MapuaUniv 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Cancer drugs that appear effective in lab tests do not always perform the same way in the body, complicating the search for effective osteosarcoma treatments. To better reproduce the tumor environment during preclinical testing, researchers developed a practical 3D osteosarcoma model using alginate microfibers, some containing a bone-like mineral. Over 21 days, cells remained viable and metabolically active while forming tissue-like aggregates and extracellular matrix components. When exposed to doxorubicin, cells grown in the 3D model showed up to sixfold greater resistance than those in conventional 2D cultures. More realistic modeling of osteosarcoma drug response could improve how potential therapies are screened and prioritized, providing stronger evidence for decisions about which should advance in development. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Evaluation of a Simple 3D Bioengineered Model: A Step Closer to Bridging the In Vitro–In Vivo Gap in Osteosarcoma Research 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Jelena Petrovic, Ivana Banicevic, Luka Bojic, Milena Milivojevic, Radmila Jankovic, Bojana Obradovic, and Jasmina Stojkovska @Univerzitet_BG @IMGGE @UBmedicinski 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

People who rely on heart pumps need devices that can adapt to changing activity levels while using less power. Researchers addressed this by developing a real-time control algorithm that automatically adjusts left ventricular assist device (LVAD) speed based on the energy used to maintain magnetic levitation. They tested the algorithm in a previously validated numerical mock circulatory loop coupled with a detailed LVAD model. In simulations, the controller increased circulatory support during exercise while allowing lower pump speeds during sleep without compromising hemodynamic output. Reducing power use while adapting support to changing demands could help make wireless charging practical – paving the way for devices that lower infection risk and respond more naturally to everyday life. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Automatic Speed Modulation Based on Real-Time Cardiac Activity Monitoring for a Next-Generation LVAD 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Phong Hoang Tran, Nobuyuki Kurita, Chris Hoi Houng Chan, O. H. Frazier, Yaxin Wang, and Joseph Cavallaro @RiceUniversity @RiceEngineering @RiceECE @BCMHouston @Texas_Heart @BCM_Surgery 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

In some diseases, cells can undergo harmful changes in their structure and behavior, raising the question of whether those changes can be controlled without directly altering what happens inside the cell. Against this backdrop, engineers reviewed how interactions with the surrounding extracellular matrix could help regulate cell behavior. They traced how physical signals travel from adhesion sites through the cytoplasm to the nucleus, where they can shape biological processes. The authors also discussed how manipulating this mechanical environment could help control endothelial-to-mesenchymal and epithelial-to-mesenchymal transitions, as well as related reprogramming and differentiation processes. Bringing these mechanisms together could guide the development of therapeutic strategies that harness the cellular environment rather than directly targeting intracellular processes. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Mechanical Signaling From ECMs to Nuclear Envelopes in Cell Transitions and Fate Decisions: A Review and Perspective on Adhesion-Niche-Based Anti-EndMT and Anti-EMT 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Jichul Kim, Hayeong Jang, Ye Eun Song, and Soo-Hong Lee 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Brain–computer interfaces can translate imagined movements into actions, but their algorithms still struggle to accurately decode different movements of the same limb. Researchers reviewed five years of work on using electroencephalography (EEG) to classify imagined upper-limb movements and identify opportunities to improve decoding. They compared state-of-the-art classification methods, their performance, and underlying assumptions while examining persistent challenges – including low signal-to-noise ratios, non-stationary signals, and difficulty distinguishing finer motions. They also assessed emerging trends and the opportunities and limitations associated with translating these approaches into real-world applications. Understanding where current methods show promise and where improvement is needed could help advance systems capable of translating increasingly specific movement intentions into more precise control of real-world technologies. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Decoding Upper-Limb Motor Imagery from EEG Signals: A Systematic Review of Methods and Applications 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Zhendong Su, Kok Beng Gan, and Kok Swee Sim @ukm_my @mmumalaysia 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

In heart failure, changes within the myocardium – the heart muscle – can disrupt oxygen delivery to cells, potentially contributing to further cardiac dysfunction and disease progression. Exploring this disruption, researchers developed a histology-image-based computational model to investigate how enlargement of the space between cardiac cells and reactive interstitial fibrosis affect oxygen delivery from capillaries. Their analysis found that both structural remodeling and fibrosis-related changes in tissue properties impaired oxygenation, with levels in heart muscle cells approximately 47% lower in severe fibrosis than in normal tissue. The balance between capillary area and interstitial area strongly predicted oxygenation, reflecting the combined effects of available supply and the distance oxygen must travel through tissue. Linking measurable structural features with cellular oxygen levels could ultimately help identify when impaired oxygenation may be contributing to worsening heart function, informing future approaches to heart failure treatment. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Oxygen Transport Impairment in the Failing Heart: A Histology-Image-Based Computational Analysis 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Haifeng Wang, Mythri Tumbalam Gooty, @dlanfearMD, Hani N. Sabbah, and Lik-Chuan Lee @michiganstateu @MSU_EGR @HenryFordHealth 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Treating obstructive sleep apnea with mandibular advancement devices depends on keeping the lower jaw sufficiently forward to support an open upper airway throughout sleep. Researchers examined how the design of these devices affects their ability to maintain lower jaw positioning as the mouth opens. Using validated mathematical models, they simulated jaw movement with seven widely used devices across 21 individuals and found that: 🔹 Bar-based devices generally maintained advancement more effectively than fin-based designs, although performance varied with bar length, joint position, and facial morphology. 🔹 Shorter bars and more forward-positioned joints produced greater protrusion, while devices with fins consistently allowed the jaw to move backward during mouth opening. These findings could inform more personalized device selection and design, helping clinicians tailor oral appliance therapy to an individual’s craniofacial anatomy and mandibular movement. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Performance of Mandibular Advancement Devices When Opening the Mouth 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Juan A. Cabrera, Alex Bataller, Pedro Mayoral, and Javier Pérez @infoUMA @IndustrialesUMA @UCAM 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Compression therapy is widely used for swelling, circulation problems, and ligament injuries, creating a need for devices that can serve diverse therapeutic applications. Engineers reviewed 86 studies examining chronic venous insufficiency, edema, ligament injury, and theoretical models of compression to identify shared biomechanical principles that could guide device development. Across these conditions, compression was found to reduce transmural pressure, increase interstitial pressure, and increase joint stiffness, while theoretical models showed how it regulates tissue geometry, fluid balance, and stiffness. Therapeutic effects also depended on how pressure was applied – including static or dynamic operation, distribution and level, and location. This synthesis could inform the design of compression devices that more deliberately control tissue mechanics and fluid behavior to achieve the intended therapeutic effect. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Compression Therapy in Human Body Applications: A Systematic Review from Principles to Practice 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Pengfei Han, Malte Asseln, Gabrielle Tuijthof, and Izadyar Tamadon @UTwente 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Blood pumps can sustain circulation in people with severe heart disease, but current testing of these devices may not adequately capture factors associated with persistent bleeding and clotting risks. To examine one important part of this problem, researchers conducted a review of 39 studies assessing platelet function in mechanical circulatory support devices. Experimental approaches varied substantially in duration, loop design, pump type, and anticoagulation, while flow cytometry emerged as the predominant method for directly evaluating changes in platelet state. The authors point to a need for standardized protocols and complementary biomarkers that can better characterize how device-generated forces alter platelet function. Deeper insight into the strengths and limitations of blood pump testing methods could inform design improvements that minimize harmful changes in platelet function, potentially reducing bleeding and clotting complications during mechanical circulatory support. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗥𝗲𝘃𝗶𝗲𝘄: Hemocompatibility of Mechanical Circulatory Support Devices: An Integrated Review of Platelet Function Assessment in In-Vitro Blood Experiments 𝗔𝘂𝘁𝗵𝗼𝗿𝘀: Xiangyu He, Michael B. Fischer, Daniel Zimpfer, Alice Assinger, and Marcus Granegger @MedUni_Wien @LBG_research 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…

Repairing large bone defects with 3D scaffolds depends on keeping cells alive throughout the structure – a challenge when oxygen cannot reach its deepest regions. To address this limitation, researchers tested whether flowing fluid through porous silk fibroin scaffolds with hollow channels could improve oxygen delivery and support bone formation. Scaffolds with 0.5- or 1-millimeter channels provided more even oxygen delivery and cell distribution, while combining the channels with fluid flow increased cell numbers, collagen production, and mineralization. Adding channels reduced compressive strength but did not alter the scaffolds’ porous structure, degradation rate, or stiffness, and modeling showed that they remained mechanically resilient under the tested strain. More effective tissue formation within larger engineered grafts could ultimately expand reconstructive options for bone defects that currently require complex surgical repair, providing a path toward more viable regenerative approaches. 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲: link.springer.com/article/10… 𝗦𝘁𝘂𝗱𝘆: Perfusion Cell Culture Induces Oxygen Diffusion and Osteogenic Activity in Multi-Channeled Critical-Size Silk Fibroin Scaffolds with Pre-Osteoblasts: Experimental and Finite Element Modeling Study @UvA_Amsterdam @VUamsterdam @ut_newsline 𝗦𝘂𝗯𝗺𝗶𝘁 𝘆𝗼𝘂𝗿 𝗺𝗮𝗻𝘂𝘀𝗰𝗿𝗶𝗽𝘁: link.springer.com/journal/10…