accelerating science for a healthier world
Seattle, WA
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What if the next breakthrough for human health, climate resilience, or clean energy isn’t waiting to be found in nature, but is waiting to be designed?
Today, we’re launching AI BioDesign, a bold endeavor to explore the uncharted design space of life.
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Our #CellLineOfTheWeek is PCNA - illuminating a protein involved in DNA replication and repair!
🧫 Our #StemCell lines and plasmids are openly available to accelerate scientific discovery: allencell.org/cell-catalog.h…
📦 Distributed by @Coriell_science and @Addgene
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#openscience in action/
Using the Allen Brain Cell Atlas, Sora Mitamur is uncovering new insights into the cellular organization and gene expression patterns of the ventral striatum through computational analysis.
Explore the ABC Atlas: brain-map.org/bkp/explore/ab…
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"For me, biology is ultimately a design challenge."
Sanjay Srivatsan, principal investigator of AI BioDesign, says new accelerator will use AI to understand biological patterns and use those patterns to inspire solutions to biological problems. bit.ly/4yoOmm9
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How does a small pool of stem cells build a brain with hundreds of cell types, each in the right place? A new Nature paper from UCSF and the Allen Institute follows the forebrain's family tree to find out. Read the paper in Nature: go.nature.com/4hzn31v
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"An exciting opportunity to make fundamental discoveries." Applications for the Shanahan Foundation Fellowship at the Interface of Data and Neuroscience are now open! Experience in #neuroscience is not needed. Apply by Dec. 1: bit.ly/4h762LH
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Applications are open for the Studio D3 Fellowship at the Allen Institute! This 3-year fellowship empowers recent PhDs with quantitative backgrounds to apply computational and theoretical approaches to biology's most complex challenges. Apply by 12/1 alleninstitute.org/studio-d3…
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"This is the best time in the history of humanity." AI BioDesign co-director Sanjay Srivatsan (@fredhutch) on why, via @KING5Seattle: AI is letting scientists design proteins nature never made, opening new paths to cancer therapies and vaccines. bit.ly/4yXZYfR
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Dive into the intricate connections in the mouse brain! 🧠✨
This video shows reconstructed neurons projecting from the thalamus to various regions of the cortex. Each neuron was fluorescently labeled and imaged with our cutting-edge ExA-SPIM microscope.
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Twenty years ago, on this day in 2006, Allen Institute for Brain Science announced the completion of our inaugural project: a web-based, 3D map of gene expression in the mouse brain providing scientists with a level of data previously not available. #openscience
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SON is our cell line of the week! SON and its associated plasmid illuminates nuclear speckles, a real science word for proteins in the nucleus involved in gene expression.
Thanks to our partners at @Coriell_Science and @addgene for helping us make our cell lines accessible.
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"What else is possible, and how can we test it?"
David Baker on AI BioDesign — the new $95M Allen Institute, UW & Fred Hutch effort to design proteins nature never made, with all data shared freely.
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Could this new brain map help fight diseases like ALS and dementia?
Our scientists and collaborators have created the most detailed map yet of the mouse motor cortex, identifying 16 distinct subregions with their own patterns of connections.
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Using 547 experiments and the Allen Institute’s foundational connectivity atlas, the map shows how motor cortex regions connect with areas involved in movement, planning, and decision-making. bit.ly/3V6sm0R
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This precision map gives researchers a shared reference for studying the motor cortex, and could help advance understanding of diseases such as ALS and frontotemporal dementia. The study was published today in Cell: bit.ly/4rpKaA0
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Nature has been inventing proteins for billions of years, but it hasn't tried everything. David Baker co-leads AI BioDesign, our new accelerator in collaboration with @uwmedicine and @fredhutch, to design molecules that could break down plastic and target cancer with precision.
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Read Jorge Garay's coverage of AI BioDesign for @WIRED: bit.ly/4drEwrm
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A big thank you to @biolamina for sponsoring our Stem Cell and Developmental Biology Early Career Symposium! Support like this is what makes it possible to bring together the next generation of researchers to share their science, build connections, and launch what comes next.
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