Early mammalian development, genetic engineering, live imaging. Assistant professor @Princeton.
Princeton, NJ
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Eszter Posfai retweeted
Very excited to serve as a Co-Instructor for the 2025 @CSHLMouseCourse June 2nd-22nd! Applications are due March 1st. Please RT!
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Eszter Posfai retweeted
An intriguing mechanism of germline cyst formation through innovative live imaging in fetal mice gonads, and computational modeling.
Check out my dispatch in @CurrentBiology on this beautiful work.
kwnsfk27.r.eu-west-1.awstrac…
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New paper alert!
Amazing grad students @levy_ezra and Isabella Leite live image female germline cyst formation in embryonic gonads of mice and discover that even as these structures form, through divisions with incomplete cytokinesis, germ cells are incredibly motile.
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Moreover, we show that this randomly oriented motility drives occasional cyst fracture events, breaking the connections between germ cells and leading to cysts with variable sizes.
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Very excited to see what this new approach can teach us about germline dynamics and to understand how oocytes emerge form cysts of variable sizes.
A shout out to @CurrentBiology and our reviewers for the fantastic publishing experience!
Paper here: authors.elsevier.com/a/1k7fg…
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Eszter Posfai retweeted
The deadline for applying to the @CSHL mouse development, stem cells and cancer course is just over two weeks away on March 1st. This immersive course provides laboratory based training along with a stellar group of speakers. Please repost and apply at meetings.cshl.edu/courses.as…
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Introducing efficient prime editing in early mouse embryos, aka PEmbryo! nature.com/articles/s41587-0… Product of a wonderful collaboration with my friend and colleague @bsadamson, spearheaded by amazing trainees Ryan McNulty and @rpkimyip. In brief:
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..this is not a caveat if you are studying the developmental or physiological phenotype resulting from a specific edit. But if you are thinking about therapeutic applications… this is likely not your tool.
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Thank you to everyone involved! Brad Joyce, Antonio Mollica, @PeterJ_Chen, @pravisankar_, Benjamin Law, @davidrliu, @toettch and @EIvakine
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Eszter Posfai retweeted
Delighted to see our paper out today in @JCellBiol! Thanks to the reviewers and editors for helpful suggestions for improvements and the impressively fast turnaround. Using our mTurq2-Col4a1 mouse model we uncover new basement membrane dynamics during embryonic development🐁
Jones, Devenport et al. @PrincetonMolBio describe a new mouse model for live visualization of the basement membrane (BM) in which endogenous type IV collagen is fluorescently labeled. bit.ly/3t0oYHb
#Adhesion #Development
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Eszter Posfai retweeted
Delighted to share our new pre-print and introduce the mTurq2-Col4a1 mouse model in which collagen IV is endogenously tagged - thanks to all authors! A Window into Mammalian Basement Membrane Development: Insights from the mTurq2-Col4a1 Mouse Model biorxiv.org/content/10.1101/…
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Eszter Posfai retweeted
Job alert: We're looking for a new cell biology faculty member here @PrincetonMolBio.
I can say that the past 8 years here have easily been the most fun & fulfilling in my research career. Apply to be our colleague! (deadline Nov 1)
puwebp.princeton.edu/AcadHir…
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Eszter Posfai retweeted
Tuesday, March 21 is the housing deadline for the 2023 Mid-Atlantic SDB Regional Meeting @Princeton. Don't miss the MASDB group rate! sdbonline.org/masdb2023
Do you have an exciting story to share about development of your favorite model system? 🐭🪱🐛🌿🐠🦎🪰🐣🐸🐢🦑🦟🦞
You're in luck - there's one more week until the abstract deadline for the #masdb Mid-Atlantic SDB! (And - no abstract submission fees!)
Come join us! @SocDevBio
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Wonderful collaboration with Stas Shvartsman’s group, including Lisa Brown, @yelnunnedyah , and @bingluns, establishing robust 3D nuclear instance segmentation for time lapse datasets of developing preimplantation mouse embryos.
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-5 different neural nets benchmarked, with Stardist-3D showing superb performance across all preimplantation stages
Stay tuned for what this method is allowing us to do!
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Shout out to everyone involved! @rpkimyip, Brad Joyce, Zsombor Gal, @maddyfoux, @AbrahamKohrman, @AlisonKickuth, Aaron Watters, Prateek Grover and Jaspreet Singh
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