Systems Biology, Epigenetics, X-chromosome inactivation Lise-Meitner Research Group Leader @MPI_MolGen in Berlin, @eddaschulz.bsky.social
Berlin, Deutschland
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📢 New preprint from the lab!
CRISPR-screening wizard 🧙 🧬 @TSchwammle figured out how different signals 🚦 are integrated at the Xist locus.
See his tweetorial below.
biorxiv.org/cgi/content/shor…
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Edda Schulz retweeted
@LabSchirmer, @PlathLab @The_Lei_Team, Giacomo Cavalli lab @CNRS, @EddaGSchulz, @deWitlab, @MJordanRowley, @LabNamekawa, @PalancadeLab, Michael Levine lab @PrincetonMolBio, @MelikeLak, @daph_cabi, @jbrickner, Noriko Saitoh lab (The Cancer Inst Hospital of JFCR), @MustafaMir16
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Edda Schulz retweeted
PhD position available in my lab - Fully funded!
Please, apply or RT! 👩🔬🐭🧫
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Together with PhD student @AlexandraMMar we wrote a News&Views @NatureGenet about the new paper📜 from @xielablife. A stunning data set on the 3D chromatin structure of the X chromosome in early embryos reveals unexpected large-scale structures: 🐭🧬🔺🔺nature.com/articles/s41588-0…
One of the X chromosomes in females is silenced with a microscopically distinct chromatin configuration. Happy to share our latest work on deciphering how the X chromosome folds during its inactivation for the first time in mouse female embryos!
nature.com/articles/s41588-0…
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Edda Schulz retweeted
Our new work is out today! Long time in the oven, this has been a really fun and informative collaboration led by Dhanur Iyer in my lab and @HK_Heidar from @NRivron lab. We show that human embryonic cells have an inherent potential to regulate their developmental timing.
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Don't miss Daniela Cecalev @cecalev's review on "Compensation of gene dosage on the mammalian X" together with Beatriz Viçoso and myself, for a comprehensive look into X upregulation and inactivation! ⬆️⬇️
journals.biologists.com/dev/…
With support from @FRM_officiel and @laliguecancer
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Ready to lead your own research team-?😎The Max Planck Society offers you the chance to head an independent Research Group at a participating Max Planck Institute of your choice - the next open topic call starts on Sep 9, 2024. Stay tuned for updates!🌟
mprg.mpg.de
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Edda Schulz retweeted
if you are passionate about the therapeutics of the future and want to be part of the 'RNA revolution' apply for this project in our lab: we want leverage the latest AI models for the prediction of potential small molecules targeting RNAs in the cell! t.ly/BjO5o
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Congratulations, Valerie!!
New job, starting next summer! Extremely excited to join the extraordinary scientific environment at @UniBasel and the @DepBiomedicine.
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📢 WE ARE HIRING! We offer a position as Research Technician in Stem Cell Biology to work in sex differences in neurodevelopmental disorders and human X chromosome inactivation.
More info:
werkenbijerasmusmc.nl/en/vac…
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Edda Schulz retweeted
on unimodal setpoints and how to get them from synthetic promoters...
tweetorial coming soon...
or see you next Thursday #SEED2024 in Atlanta...
Stay tuned for more control systems coming soon...
Programmable promoter editing for precise control of transgene expression
ift.tt/RchaKp6
#biorxiv_synbio
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It was a pleasure to write this review together with @nellykanata and Rachel Duffie @sneexish from the Lomvardas lab on the principles that govern monoallelic expression of olfactory receptors and Xist for @Dev_journal
Establishment and maintenance of random monoallelic expression
In this Review, @nellykanata, @sneexish & @EddaGSchulz @MPI_MolGen give an overview of the regulatory mechanisms and current models for establishment and maintenance of monoallelic expression:
journals.biologists.com/dev/…
ALT figure 2: The establishment of monoallelic Xist expression.
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Edda Schulz retweeted
Ever wondered how 3D chromatin rewires during differentiation? We wanted to understand this process better & distinguish if different processes or elements drive this rewiring. To do so, we used mESC=>NPC differentiation and focused on a single locus. biorxiv.org/content/10.1101/… 1/17
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Edda Schulz retweeted
Mary Lyon FRS was born #OnThisDay in 1925. Lyon was the discoverer of X-chromosome inactivation, which the genetic process that leads to coloration like tortoiseshell cats. Read more about her discoveries in a new @RSocPublishing biographical memoir: royalsocietypublishing.org/d…
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Edda Schulz retweeted
Climate experts were increasingly saying that keeping heating below 1.5C is near impossible, yet it remains the global goal. So I asked hundreds of top IPCC scientists what they thought. What they said shocked even me…
🧵 1/n #ClimateCrisis
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Edda Schulz retweeted
📢Time to voice our concerns about the #WissZeitVG once again!
➡️17 scientific societies, which together represent more than 55,000 scientists, are speaking out!
👉Please share our initiative!
🔁Please RT
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Edda Schulz retweeted
🥼 Open PhD position!
🌞🌞We are recruiting new lab members in the beautiful Seville
🗣️Please RT!
👋Contact me if you are interested: fmarrea@upo.es
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Edda Schulz retweeted
WRT the recent interest in TbxT, aka #Brachyury, & all kind of tails, nice historical perspective on this most iconic gene in the history of #DevBio shorturl.at/lEK57. Below, heroes of Brachyury (Fig.2 in ref ) + B. Herrmann, who cloned the gene &, of course, the T/+ mouse
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Edda Schulz retweeted
🔬🧬 Exciting PhD Opportunity!
I am looking for a motivated PhD candidate with a strong profile in mammalian epigenetics and gene regulation to strengthen my team at SILS (University of Amsterdam).
Application deadline March 21st
For more details, tinyurl.com/hznwtjmb
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