JAMA Network Open@JAMANetworkOpen

JAMA Network Open is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.

 Chicago, IL
jamanetworkopen.com
Joined April 2017
5,061 Photos and videos
Among veterans seeking primary care for #LowBackPain, a sequenced care pathway was not superior to a pain navigator pathway for improving pain interference or physical function at 3 months. 馃敆 ja.ma/3Vs32T3
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馃摚 This JAMA+ Trials Theme of the Month examines how #pragmatic clinical trials are intended to generate evidence for real-world clinical decisions without sacrificing research rigor. 馃摤 Learn more about this trial and subscribe to the newsletter: ja.ma/4y3sVHd

JAMA+ Trials Research, Education and Commentary from JAMA Network

Find high-quality clinical trial research with JAMA+ Trials, offering curated studies, multimedia insights, and advanced search across the JAMA Network.

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JAMA+ Trials@JAMAplusTrials
Sep 21
馃摙 Share your opinion: New JAMA+ Trials Poll! How many clinical trials that claim to be "pragmatic" actually provide useful evidence for real-world decision-making? 馃搳 Vote now and join the discussion: ja.ma/4h5U1rm #ClinicalTrials #Research #Evidence
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馃搱 Integrating #SmokingCessation treatment into #LungCancerScreening was cost-saving vs screening alone, with higher-intensity pharmacotherapy and counseling associated with the greatest long-term health gains. ja.ma/46put28
A scatter plot shows QALYs (thousands) on Y-axis vs. total lifetime costs (million $) on X-axis. 'HighMED + HighCSL' shows highest QALYs (2269k) at $1545M cost. 'Screening alone' is lowest at 2240k QALYs for $1630M. Other strategies vary between.

ALT A scatter plot shows QALYs (thousands) on Y-axis vs. total lifetime costs (million $) on X-axis. 'HighMED + HighCSL' shows highest QALYs (2269k) at $1545M cost. 'Screening alone' is lowest at 2240k QALYs for $1630M. Other strategies vary between.
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馃搱 Among infants who were tested for respiratory syncytial virus (#RSV) in 2 Canadian provinces, receipt of #Nirsevimab was associated with lower risk of RSV-related emergency department visits, hospitalization, and intensive care unit admission. ja.ma/4cGdHPV
Bar and line graph showing the number of infants with positive RSV test results (bars) and infants with nirsevimab immunization (line) from Oct 27, 2024 to Feb 23, 2025. RSV peaks around 75 in early Dec, while immunization peaks around 60 in early Nov, then both decline.

ALT Bar and line graph showing the number of infants with positive RSV test results (bars) and infants with nirsevimab immunization (line) from Oct 27, 2024 to Feb 23, 2025. RSV peaks around 75 in early Dec, while immunization peaks around 60 in early Nov, then both decline.

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馃搳 Among patients at #HRSA health centers, #FoodInsecurity was associated with more referrals to food assistance, but more than one-third of food-insecure patients reported receiving neither SNAP or WIC nor a referral. ja.ma/4dfnuwu
Bar chart shows patient percentages by food security (insecure/secure) and DRHC referral status (No DRHC/DRHC). Bars represent SNAP/WIC enrollment and referral source: from health center (dark gray/orange) or no referral from health center (light blue/light orange).

ALT Bar chart shows patient percentages by food security (insecure/secure) and DRHC referral status (No DRHC/DRHC). Bars represent SNAP/WIC enrollment and referral source: from health center (dark gray/orange) or no referral from health center (light blue/light orange).
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馃搳 Among older inpatients with #Malnutrition at admission, implementation of a nutrition clinical framework was associated with lower in-hospital mortality and shorter length of stay. ja.ma/4xkqMpr
Five line graphs compare \"Wards without framework\" (dark circles) to \"Wards with framework\" (orange squares, dashed line) from January 2022 to January 2026. Metrics are in-hospital, 6-month, 1-year, and overall mortality, and length of stay. \"Wards with framework\" generally show lower values across all metrics. A shaded area and dotted line mark a period in late 2023-early 2024.

ALT Five line graphs compare \"Wards without framework\" (dark circles) to \"Wards with framework\" (orange squares, dashed line) from January 2022 to January 2026. Metrics are in-hospital, 6-month, 1-year, and overall mortality, and length of stay. \"Wards with framework\" generally show lower values across all metrics. A shaded area and dotted line mark a period in late 2023-early 2024.
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馃 In #MajorDepressiveDisorder, gray matter volume trajectories over 10 years were associated with cumulative illness burden rather than diagnosis alone or acute symptom fluctuations. ja.ma/4A9zgCs
Brain scans highlight dLPFC & Hippocampus. Two graphs show estimated age-adjusted GMV over 10 years by CIS quartile. For both regions, the highest CIS quartile (Q4) exhibits a marked decline in GMV, while lower quartiles remain stable.

ALT Brain scans highlight dLPFC & Hippocampus. Two graphs show estimated age-adjusted GMV over 10 years by CIS quartile. For both regions, the highest CIS quartile (Q4) exhibits a marked decline in GMV, while lower quartiles remain stable.
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馃搳 Among survivors of #BreastCancer in a longitudinal cohort, nonresponsiveness increased over time and was associated with social vulnerability, unhealthy behaviors, symptom burden, and enrollment at smaller centers. ja.ma/4xtlSXg
Stacked bar chart showing patient status from Baseline to Year 6 follow-up. The Y-axis is Patients, %. 'Responsive' patients decline from nearly 100% to ~75%. 'No response from enrolled patients,' 'Lost to follow-up,' and 'Withdrew consent' categories collectively increase, reaching ~25% by Year 6.

ALT Stacked bar chart showing patient status from Baseline to Year 6 follow-up. The Y-axis is Patients, %. 'Responsive' patients decline from nearly 100% to ~75%. 'No response from enrolled patients,' 'Lost to follow-up,' and 'Withdrew consent' categories collectively increase, reaching ~25% by Year 6.
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馃搳 Perceived good death priorities differed across settings, while patient-caregiver differences were generally small, supporting culturally sensitive #PalliativeCare that reflects both shared and setting-specific end-of-life values. ja.ma/4cLJvmu
JAMA Network Open article: \"Perceived Importance of Good Death Components Among Patients With Advanced Cancer and Family Caregivers\" by Hammoda Abu-Odah et al. An Original Investigation in Oncology, published online September 14, 2026.

ALT JAMA Network Open article: \"Perceived Importance of Good Death Components Among Patients With Advanced Cancer and Family Caregivers\" by Hammoda Abu-Odah et al. An Original Investigation in Oncology, published online September 14, 2026.
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Among Denmark children, a history of #FebrileSeizures was reassuringly associated with school test performances largely similar to that of unaffected peers. Children with many recurrences or later epilepsy may benefit from additional educational support. ja.ma/4h3582W
Table & forest plot showing test score differences by febrile seizure history, age, hospital contacts, and duration. No febrile seizures is reference (55.8). Test scores generally decrease with more hospital contacts or longer contact duration. Largest difference: -5.7 for >=7 hospital contacts. Basic & fully adjusted shown.

ALT Table & forest plot showing test score differences by febrile seizure history, age, hospital contacts, and duration. No febrile seizures is reference (55.8). Test scores generally decrease with more hospital contacts or longer contact duration. Largest difference: -5.7 for >=7 hospital contacts. Basic & fully adjusted shown.
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馃搱 In Tanzania, simulation-based #NeonatalVentilation training with a low-cost, high-fidelity simulator was associated with improved knowledge and practical performance among students and health professionals. ja.ma/4cFGzrE
Four line graphs display pressure and BPM metrics over 6 trials for Medium-fidelity passive, High-fidelity passive, and High-fidelity active groups vs. a criterion standard. A: Mean pressure, High-fidelity passive is highest, medium-fidelity passive lowest. B: CV pressure, High-fidelity active peaks at trial 4. C: BPM, High-fidelity passive highest. D: CV BPM shows downward trends.

ALT Four line graphs display pressure and BPM metrics over 6 trials for Medium-fidelity passive, High-fidelity passive, and High-fidelity active groups vs. a criterion standard. A: Mean pressure, High-fidelity passive is highest, medium-fidelity passive lowest. B: CV pressure, High-fidelity active peaks at trial 4. C: BPM, High-fidelity passive highest. D: CV BPM shows downward trends.
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馃搳 In the US, aggregate patient out-of-pocket spending on #GenericDrugs exceeded spending on #BrandName prescription drugs, even though brand-name drugs were more expensive on a per-drug basis. ja.ma/4dmug3s

Patient Out-of-Pocket Spending on Generic and Brand-Name Prescription Drugs

This cross-sectional study characterizes annual patient out-of-pocket spending on generic vs brand-name prescription drugs in the US.

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馃搳Across US patients with newly diagnosed #Cancer, diagnoses varied by calendar month. Months with a higher proportion of localized-stage diagnosis were also associated with better 5-year survival, suggesting an overlooked temporal dimension of cancer care ja.ma/4yoRI8x

Seasonal Patterns and Implications of Cancer Diagnosis Across Calendar Months

This cross-sectional study characterizes seasonal variations in the proportion of cancer diagnoses in the US across the calendar year and discusses the implications of these patterns.

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馃搱 Funding explicitly allocated for #SuicidePrevention and #CrisisServices in US state budgets increased from 2021 to 2026. Allocations were higher in states with a 988 telecom fee, suggesting this policy approach may support crisis service infrastructure. ja.ma/4ylazBl

Funding for Suicide Prevention and Crisis Services in US State Budgets

This cross-sectional study quantifies funding allocated for suicide prevention and crisis services in state budgets between fiscal years 2021 and 2026 and assesses differences in the magnitude of...

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馃彞 In hospitalized adults, the End-of-Life Care Index showed moderate to high discrimination for 1-year mortality but poor calibration across 2 large US health systems, indicating potential value for #PalliativeCare but important limits for clinical use. ja.ma/4yIzGyn

Accuracy and Equity of an End-of-Life Care Index in Predicting 1-Year Mortality

This prognostic study extends evaluation of the performance and equity of an End-of-Life Care Index across sociodemographic and diagnostic characteristics in a retrospective cohort of patients...

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馃搱 Among children and youths whose mothers experienced violent injury, risk of physical and sexual injury was higher than among unexposed children, indicating an important need for #TraumaInformed #PediatricCare ja.ma/4ylTjvE

Risk of Injury Among Children and Youths Whose Mothers Experienced Violent Injury

This systematic review and meta-analysis estimates the risk of injury among children whose mothers have experienced violent injury.

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馃搳 Medicaid beneficiaries with #AutismSpectrumDisorder face a 14-year deficit in life expectancy due to excess risk of dying from influenza, pneumonia, malnutrition, drowning, and other preventable causes. ja.ma/4ynDNzl

Autism Spectrum Disorder and Life Expectancy Among Medicaid Beneficiaries

This cross-sectional study examines the life expectancies and causes of death associated with excess mortality among Medicaid beneficiaries with autism spectrum disorder.

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馃搱 Among nulliparous patients, higher #PrepregnancyDietQuality was associated with lower risk of #AdversePregnancyOutcomes, and a a healthier first-trimester cardiometabolic profile ja.ma/464X38Z

Prepregnancy Diet Quality Index and Adverse Pregnancy Outcomes

This cohort study of US births examines the association of preconception diet quality with adverse pregnancy outcomes.

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馃搳 Among UK Biobank participants, lifelong genetic inhibition of #PCSK9 was associated with lower low-density lipoprotein cholesterol without increased liver enzyme levels or incident #ChronicLiverDisease. ja.ma/4xeaHSm

Lifelong Genetic Inhibition of PCSK9 and Hepatic Safety

This genetic association study investigates whether the full spectrum of rare PCSK9 loss-of-function variants is associated with incident liver-related outcomes, given the development of therapies...

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