Journal of Experimental Medicine@JExpMed

The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 - @RockUPress

 New York, NY
jem.org
Joined September 2009
10,671 Photos and videos
“We are very proud of our JEM article and feel that it will receive wide exposure in the community.” — Ignacio Melero, @ClinicaNavarra. Learn more about submitting to a journal valued by the community: hubs.la/Q04xy7qN0
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Read Dr. Melero and colleagues’ JEM study TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment. rupress.org/jem/article/223/…

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment

This study provides evidence for a key role of TNFR1, as expressed by malignant cells, in orchestrating a pro-tumor immunosuppressive environment through s

rupress.org
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Jiaojiao Zhang, Tian Zhao, Hong Lei, Rui Gan and colleagues identify the transcription factor GABPA as a critical regulator of STING expression, pivotal for antiviral defense and inflammatory diseases. hubs.la/Q04yXqrw0 #InnateImmunity #inflammation #Lupus #SLE
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Thornton et al. demonstrate that in #Tregs, the transcription factor Helios directly controls Tcf1, Lef1, Id3, & Bach2 to regulate effector Treg generation and terminal differentiation. Mice with Helios-deficient Tregs show #adipose-specific #autoimmunity hubs.la/Q04yXnK-0
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What’s a Journal-Based #CME activity? A full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME activity in collaboration with @MSKCME @MSKCancerCenter is NOW available 👉 hubs.la/Q04wfCYl0
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📢 Tell your friends and colleagues about JEM’s Early Career Travel Award! ✈️ 🧳 We’re providing support for #gradstudents and early-career #postdoc researchers to attend the #VIB #Neuroimmunology Conference @VIBTrainConf in Antwerp! Apply here 👉 hubs.la/Q04xTxKF0
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Jensen, Skouboe, Gervais, Mogensen et al. report the finding of #autoantibodies neutralizing type I IFNs in the blood and/or cerebrospinal fluid in a significantly elevated fraction of adults with HSV encephalitis (5%) compared with the general population. hubs.la/Q04yqRDl0
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@grvsadrian @ShenYingZhang1 @casanova_lab
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Yang Yu, Yanling Zhao, Zhongcheng Shi, Larry L. Wang et al. demonstrate that CAMKV, previously classified as a nonfunctional pseudokinase, possesses intrinsic kinase activity driven by MYC/MYCN oncogenes to promote #neuroblastoma growth. hubs.la/Q04ykZ360
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Insights: Sajiki, Araki et al. (hubs.la/Q04ykYf40) show that long-lived naive #CD8 #Tcells accrue tonic #TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. From Hee Yeun Won & Jung-Hyun Park: hubs.la/Q04ykYhq0
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New Review: Tomás S. Huerta, @KevinJTraceyMD, Isaac M. Chiu & @changsbrain review the organization & function of vagal neuroimmune circuits, from afferent cytokine sensing to organ-specific efferent immune control. hubs.la/Q04ykWBh0 #BioelectronicMedicine #Neuroimmunology
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✍️💻 Participate in a complimentary Journal-Based #CME activity that consists of a full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME Activity @MSKCME is NOW available 👉 hubs.la/Q04wgC0S0
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📢 We're now accepting applications for the JEM Early Career Travel Award, for grad students & early-career postdocs to participate in #VIB #Neuroimmunology Conference @VIBTrainConf in Antwerp! Deadline ⏰ October 16, 2026 Apply here 👉 hubs.la/Q04xTnCC0
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Ovezgeldiyev, Trefzer, Doolan, Bouchery et al. reveal a metabolic pathway linking lipid mediator production to #macrophage activation during #helminth immunity. hubs.la/Q04xS7d70 #Metabolism #InnateImmunity #inflammation #InfectiousDisease #HostDefense
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Florez-Paz & Mentis demonstrate the presence of supernumerary synapses during development, resulting in miswired immature spinal circuits. Two molecularly distinct mechanisms are responsible for their refinement, incl. a surprising CD47-dependent mechanism hubs.ly/Q04xFWyB0
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Zhang et al. identify RalA-dependent signaling as a regulator of age-related #skeletalmuscle dysfunction. The novel compound UA-30 inhibits RalA activity, reduces muscle #fibrosis, improves mitochondrial function & mobility, & extends survival in mice. hubs.ly/Q04xFVZX0
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“JEM doubtlessly is among the most prestigious journals in the overall field of medicine and in particular for the fields of immunology and inflammation.” — Ignacio Melero @ClinicaNavarra Learn more about submitting to a journal valued by the community: hubs.la/Q04xy3xQ0
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Read Dr. Melero and colleagues’ JEM study TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment. rupress.org/jem/article/223/…

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment

This study provides evidence for a key role of TNFR1, as expressed by malignant cells, in orchestrating a pro-tumor immunosuppressive environment through s

rupress.org
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322
New content is available in our journal-based #CME activities @MSKCME: 📄  “Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine” (Conde et al. hubs.la/Q04wfwBF0) Begin the activity 👉 hubs.la/Q04wfFYR0
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Explore our #cancer #Immunotherapy collection showcasing a broad range of topics, including the therapeutic potential of targeting cDC1, a strategy to harness the immunosuppressive potential of inhibitory receptors, and more: 👉 hubs.la/Q04v-Jnf0
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