Nicholas Saunderson lost his sight to smallpox as a child, yet in 1711 he became the fourth Lucasian Professor of Mathematics at Cambridge.
He lectured on optics, light, colours and vision, and developed a tactile “pin-board” for calculation and geometry: pegs placed in a grid represented digits, while threads stretched between them formed geometric figures.
A remarkable example of mathematics being understood through structure, touch and abstraction rather than sight.
Source: David Wells, The Penguin Book of Curious and Interesting Mathematics.