ALT A graph from an Original Article published in the New England Journal of Medicine article titled "Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity." The graph shows effect of retatrutide on body weight. The trial name, TRIUMPH-1, is in parentheses after the title. The NEJM identity sits at the bottom.

ALT Graph showing estimates over time of the probability of a first flare of IgG4-related disease for which rescue therapy was required. The y-axis represents the probability of no flare, ranging from 0 to 1, and the x-axis shows time in months. The blue line indicates obexelimab while gray line indicates placebo. Notable statistics detail patients at risk, number of patients with flares, and median times. The hazard ratio is 0.44 with a p-value of <0.001.

ALT A visual representation of giredestrant plus everolimus in advanced breast cancer. Two medication bottles labeled "Giredestrant" and "Everolimus" are shown with pills beside them. A plus sign is between the bottles. On the right, a simplified outline of a patient is depicted with glowing areas representing ER-positive,HER2-negative advanced breast cancer.

ALT This image is an announcement from the Signal Awards that the Intention to Treat podcast from the New England Journal of Medicine is a finalist in the Limited Series & Specials category for Health & Wellness.

ALT On the left is a quote published in the New England Journal of Medicine that reads as follows: “Ms. P. took immense pride in her ability to support others during times of need, but she’d been unprepared for the abrupt transition to requiring the kind of help that she had always so freely given.” The Perspective is titled "The Mayor" and the authors are Michael A. Incze, M.D., and Laura Stolebarger, B.S.N. The NEJM identity sits at the bottom. On the right is an illustration of a group of people standing in a circle in a room with a few chairs scattered around. A person in the center is speaking to the others.

ALT Three medical images from the Images in Clinical Medicine "Thyroglossal Duct Cyst." Panel A: A photo showing a nontender, mobile, midline mass in the anterior neck that moved up with tongue protrusion and swallowing. Panel B: Sagittal T2-weighted MRI showing a hyperintense, beaded fistulous duct originating from the tongue base, coursing inferiorly through the hyoid bone, and terminating in a cyst anterior to the thyroid cartilage. Panel C: The cyst and the central portion of the hyoid bone that were excised.

ALT An image announcing the audio interview "Benjamin D. Scher, D.Phil.: After the Opioid Settlements." There is a photo of the interviewee over a decorative soundwave graphic.

ALT An infographic that shows the ecology of Andes virus. On the left, a section labeled "Environmental or zoonotic exposure" depicts a rat, agricultural work, and camping. On the right, a section labeled "Possible person-to-person transmission" shows an individual lying on a couch, individuals interacting in social and hospital settings, and a calendar page. At the bottom, text sections describe "Most Common Exposures" and "Transmission Characteristics of Highest Concern" highlighting risk factors and concerns.

ALT A quote from an NEJM Voices blog post reads as follows: “Public trust in vaccine recommendations is not a bottomless well; we can’t continue to draw from it and recommend vaccines even when the evidence of meaningful benefit is weak.” The author is Paul E. Sax, M.D. The background color is blue and includes the NEJM Voices logo.

ALT This image is two panels showing major cardiovascular events and disability-free survival according to trial group. Panel A shows the cumulative incidence of major cardiovascular events. The graphs on the left show the cumulative incidence of primary end-point events (death from cardiovascular causes, nonfatal myocardial infarction or stroke, or coronary revascularization, whichever occurred first), and those on the right the cumulative incidence of composite secondary end-point events (death from cardiovascular causes, myocardial infarction, or stroke, whichever occurred first). Panel B shows the cumulative incidence of death from any cause, dementia, or persistent physical disability, whichever occurred first, as a measure of disability-free survival. Insets show the same data on an expanded y axis.

ALT An illustration depicting obexelimab for the treatment of IgG4-related disease. On the left, a patient with red highlighted areas on the body representing IgG4-related disease. On the right is a visual representation of obexelimab as a bifunctional monoclonal antibody that inhibits B-cell activity through coengagement of CD19 and FcγRIIb, without depleting B cells.

ALT A quote from a Perspective published in the New England Journal of Medicine reads as follows: "Companies have historically sequenced market entry in European countries on the basis of market size and the expected favorability of national assessments and pricing conditions." The Perspective is titled "Joint Clinical Assessments — A New Chapter in European Pharmaceutical Policy" and the authors are Huseyin Naci, Ph.D., M.H.S., and Beate Wieseler, Dr. rer. nat. The background color is purple and includes the NEJM identity.

ALT An immunohistochemical analysis of a a nipple-biopsy specimen. The text “Image Challenge—What is the diagnosis?” sits above the image.

ALT A quote from a Medicine and Society article published in the New England Journal of Medicine reads as follows: "The reliability problems that motivated the scientific reform movement are addressed by the methodologic practices the initiative endorses … not by reallocating decision authority to political appointees." The article is titled "Gold Standard Science and Biomedical Research — Principles, Governance, and Scientific Independence" and the author is Harvey V. Fineberg, M.D., Ph.D. The background color is beige.

ALT Still frame from a video showing graphic and text warnings highlighting the harms of tobacco on the front and back of smoked tobacco products sold in India. Overlaid on the image reads "Double Take Video: Tobacco-Cessation Treatment for Global Impact."

ALT A bar chart showing the percentages of participants who had weight reduction of at least 5%, at least 10%, at least 15%, or at least 20% from baseline to week 76 for the treatment-regimen estimand.

ALT An illustrated diagram of multisystem findings in patients with Duchenne Muscular Dystrophy. The image highlights physical features such as shoulder and arm positioning, a protruding belly, calf muscles with pseudohypertrophy, and a waddling gait. Annotations describe muscle weakness, respiratory challenges, positional deformity, and difficulty maintaining balance, leading to frequent falls.

ALT Clockwise from top left: A box labeled "Atorvastatin" with two pills is depicted; an illustration showing a heart with an exclamation mark; a silhouette of a patient with a disability; and a group of five silhouettes representing older patients.

ALT A quote from a Perspective published in the New England Journal of Medicine reads as follows: "The use of rewards for creating and maintaining a consumer base is similar to tactics used by global cigarette companies for decades." The Perspective is titled "Vaping for Crypto — Smart Devices, Risky Business" and the authors are Amanda M. Palmer, Ph.D., Tracy T. Smith, Ph.D., and Benjamin A. Toll, Ph.D. The background color is green and includes the NEJM logo.