ALT The Guliya ice cap (GIC) is the largest body of ice in the western Kunlun Mountains in the Tibetan Plateau. Ice cores drilled on the GIC preserve the record of past climate change in the region, an area which provides water for several billion people in Central and South Asia. Thompson et al. analyzed ice cores drilled in 1992 and 2015 and used cosmogenic isotopes and Asian monsoon records to construct an accurate climate timescale extending back 128,000 years, the oldest ice-core-derived climate record from the Tibetan Plateau. The timeline supports the presence of glacial-stage ice in the GIC, confirming that GIC ice is over 100,000 years old. Credit: Lonnie G. Thompson

ALT Illustration of Acoustofluidic Cryo-EM (ACE), a specimen preparation strategy that uses acoustic waves to enhance cryo-electron microscopy. In developing ACE, Yang et al. integrated acoustofluidic manipulation into a conventional plunge-freezing workflow, preserving the structural integrity of samples while improving imaging quality. The sound waves eliminate contamination as no physical tools are needed, helping prevent damage when capturing images and ensuring a more uniform distribution of nanoparticles. ACE provides a method to improve specimen quality and imaging efficiency and expand structural studies of challenging biological systems. Credit: Jun Huang, Ying Chen, and coauthors