Sarafan ChEM-H@Stanford_ChEMH

Bridging chemistry, engineering, biology & medicine to advance human health, transform research, and train the next generation of scientific leaders @Stanford

 Stanford, CA
chemh.stanford.edu
Joined April 2018
1,615 Photos and videos
“It’s hard for me to think of a field it wouldn’t transform.” Institute Scholar Polly Fordyce @fordycelab is working to build the world's largest dataset on how proteins actually function, to help AI design new antibodies, enzymes, and medicines. brnw.ch/21x67Kk

The protein observatory

Polly Fordyce is building a global engine for protein discovery—one that could help researchers harness AI to create new medicines, materials, and climate solutions.

openminds.stanford.edu
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Sarafan ChEM-H retweeted
Long Lab@longlabstanford
Sep 30
Lac-Phe is an exercise💪 and metformin💊 inducible blood-borne metabolite that suppresses appetite. How does Lac-Phe get into circulation? New from @Shuke_Xiao: a transporter deorphanization story that links local cellular metabolism to systemic activity: biorxiv.org/content/10.64898…

MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss

Metabolites are increasingly recognized as circulating molecules that regulate physiology, yet the mechanisms that couple intracellular production to organism-wide action remain poorly defined. Using...

biorxiv.org
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Sarafan ChEM-H retweeted
Joseph C Wu, MD, PhD@Joseph_C_Wu
Sep 28
🫀 New in @CircAHA. We systematically developed a "HFpEF" cocktail to model impaired cardiac relaxation across human heart cells, organoids, and engineered tissues. Congratulations to all authors! @StanfordCVI @StanfordMed @GreenstoneBio @Stanford_ChEMH ahajournals.org/doi/10.1161/…

Modeling Heart Failure With Preserved Ejection Fraction Using Human Induced Pluripotent Stem...

ahajournals.org
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🧬 Join us Oct. 14 for the IICD Seminar Series! Dr. Paul Mischel of @Stanford presents “Extrachromosomal DNA (ecDNA): Cancer’s Dynamic Circular Genome.” 📅 Oct. 14 | 2 PM ET | Zoom 🔗 cancerdynamics.columbia.edu/…
Banner for IICD Seminar Series on October 14 featuring Dr. Paul Mischel from Stanford University

ALT Banner for IICD Seminar Series on October 14 featuring Dr. Paul Mischel from Stanford University
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Join us for the CRB60 Symposium, celebrating our director Carolyn Bertozzi's legacy and impact on chemical biology, with talks from her lab alumni! Oct 9, 2026, Paul Berg Auditorium, Stanford. Register here: brnw.ch/21x64tQ @UCB_Chemistry
Speakers: Nicholas Agard • Genentech Steven Banik • Stanford Michael Boyce • Duke Xing Chen • Peking University Penelope Drake • 16 Waves Danielle Dube • Bowdoin Ryan Flynn • Harvard Zev Gartner • UCSF Howard Hang • Scripps Matt Hangauer • UC San Diego Ramesh Jasti • Oregon Jennifer Kohler • UTSW Jessica Kramer • Utah Lara Mahal • Alberta Stacy Malaker • Yale Lisa Marcaurelle • GSK Matthew Pratt • USC Jennifer Prescher • UCI Benjamin Schumann • TU Dresden Sloan Siegrist • UMass Amherst Ellen Sletten • Dartmouth David Vocadlo • Simon Fraser Christina Woo • Harvard Peng Wu • Scripps

ALT Speakers: Nicholas Agard • Genentech Steven Banik • Stanford Michael Boyce • Duke Xing Chen • Peking University Penelope Drake • 16 Waves Danielle Dube • Bowdoin Ryan Flynn • Harvard Zev Gartner • UCSF Howard Hang • Scripps Matt Hangauer • UC San Diego Ramesh Jasti • Oregon Jennifer Kohler • UTSW Jessica Kramer • Utah Lara Mahal • Alberta Stacy Malaker • Yale Lisa Marcaurelle • GSK Matthew Pratt • USC Jennifer Prescher • UCI Benjamin Schumann • TU Dresden Sloan Siegrist • UMass Amherst Ellen Sletten • Dartmouth David Vocadlo • Simon Fraser Christina Woo • Harvard Peng Wu • Scripps
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Hear our director Carolyn Bertozzi in @StanfordBrain's new podcast episode on the sugar molecules coating our cells- work so complex she created a new field, bioorthogonal chemistry, to study them - now fueling drug development for cancer & other diseases: brnw.ch/21x63f0

Sugar on the brain

We talk with Carolyn Bertozzi about her Nobel Prize-winning work in chemistry – and the impact it could have on neuroscience

neuroscience.stanford.edu
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Sarafan ChEM-H retweeted
Michael Lin, MD PhD 🧬@michaelzlin
Sep 25
Replying to @Stanford_ChEMH
We started RASER as a ground-up protein engineering and math project (with help from Jim Ferrell in Chemical and Systems Biology), then applied it to solve the longstanding problem of how to make cancer virotherapy safer and more effective. Paper link: nature.com/articles/s41551-0…

Rewiring oncogenic signalling to precision ablation of metastatic cancer

Nature Biomedical Engineering - An engineered ErbB oncogene-selective virus shows improved safety and efficacy for treating mouse models of ErbBr/HER2 positive ovarian cancer, showing promise for...

nature.com
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Sarafan ChEM-H retweeted
Sergiu P. Pasca
@Sergiu_P_Pasca
Sep 25
Here’s a short summary of our recent #xenocortication article in @Nature, including the rationale, approach, key findings, initial applications to disease modeling, and current limitations. A tremendous effort led by Konstantin Kaganovsky, Kevin Kelley, Tilo Gschwind, and Paul Harary. Link to the article below
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#ICYMI Faculty Fellow @michaelzlin and team have developed RASER, a novel therapeutic approach that sharpens the precision of certain cancer treatments while sparing healthy tissue: brnw.ch/21x5XUz

Cutting through cancer with RASER: A new approach to metastatic disease

By prioritizing treatment precision and minimizing toxicity, the RASER system offers hope for patients living with metastatic cancers.

med.stanford.edu
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Sarafan ChEM-H retweeted
Joseph C Wu, MD, PhD@Joseph_C_Wu
Sep 24
🎉 I'm excited to share our @ScienceMagazine study on "Targeting an atypical G protein-coupled receptor signaling pathway for cardiac fibrosis therapy". Congrats to all co-authors. @StanfordCVI @StanfordMed @StanfordDeptMed @Stanford_ChEMH @GreenstoneBio doi.org/10.1126/science.aej5…

Targeting an atypical G protein–coupled receptor signaling pathway for cardiac fibrosis therapy

Cardiac fibrosis independently predicts adverse outcomes in heart failure (HF), yet no Food and Drug Administration–approved therapy directly targets fibrotic remodeling in the heart. To address this...

science.org
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Sarafan ChEM-H retweeted
Stanford Chemistry@StanfordUChem
Sep 23
🎙️ Listen to Prof. Carolyn Bertozzi on "From Our Neurons to Yours" podcast, where she discusses glycans—sugar molecules that play key roles in cell communication, immunity, and disease—and her pioneering work in bioorthogonal chemistry. brnw.ch/21x5UTD

Sugar on the brain | Carolyn Bertozzi

Podcast Episode · From Our Neurons to Yours · September 11 · 52m · Video

podcasts.apple.com
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CBI trainee Isaac Paddy in the lab of Institute Scholar Laura Dassama and in collaboration with Institute Scholar @JacobsWagnerLab explores the metabolic vulnerabilities of the pathogen that causes Lyme disease in the hope of finding new treatments: brnw.ch/21x5UI5

A cofactor‐promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial...

The Lyme disease pathogen Borrelia burgdorferi contains a highly reduced genome lacking many primary metabolic pathways. However, B. burgdorferi retains the mevalonate pathway that synthesizes...

onlinelibrary.wiley.com
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We're hiring! The Microbiome Therapies Initiative (MITI) at Sarafan ChEM-H is seeking a highly motivated protein scientist for a role in our ambitious new effort to develop and produce commensal vaccines in-house at Stanford for clinical use. Learn more: chemh.stanford.edu/opportuni…
Decorative

ALT Decorative
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Sarafan ChEM-H retweeted
ASBMB@ASBMB
Sep 17
A discovery about how viruses enter cells launched a career focused on translating molecular insights into therapies and vaccines. Learn more about Peter Kim's scientific journey ahead of his keynote address at #ASBMB2027: asbmb.org/asbmb-today/people…. @Stanford_ChEMH | @StanfordMed
ASBMB Annual Meeting 2027 keynote speaker graphic featuring Peter S. Kim of Stanford University and former president of Merck Research Laboratories. Meeting dates: April 3–6, 2027, in Boston.

ALT ASBMB Annual Meeting 2027 keynote speaker graphic featuring Peter S. Kim of Stanford University and former president of Merck Research Laboratories. Meeting dates: April 3–6, 2027, in Boston.
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Most of our cells are covered in sugars. What can they tell us about the brain? Nobel Prize-winning chemist Carolyn Bertozzi shares what these sugars may reveal about the aging brain and how this research could impact neuroscience and drug development. neuroscience.stanford.edu/ne…
Nobel Prize-winning chemist Carolyn Bertozzi is the Baker Family Director of Sarafan ChEM-H and the Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences.

ALT Nobel Prize-winning chemist Carolyn Bertozzi is the Baker Family Director of Sarafan ChEM-H and the Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences.
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Institute scholar @nicolemmart & team have developed a method to examine how special enzymes called pseudouridine synthases chemically alter RNA molecules within cells, giving clues to how these enzymes may be regulated and dysregulated in disease: brnw.ch/21x5Nub

Writing the playbook for RNA-modifying enzymes and their roles in regulating translation of the...

Institute scholar Nicole M. Martinez and team have developed a quantitative method to examine how special enzymes called pseudouridine synthases chemically alter RNA molecules within our cells

chemh.stanford.edu
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With @gatesfoundation funding, a collaboration between @Stanford, @BelmontUniv & @BiostructA will train African scientists in cryo-EM, an advanced technique to study HIV and other infectious diseases and design new therapeutics: brnw.ch/21x5JPg @cobarnes27 @BarnesLab1

Multi-institutional collaboration brings advanced microscopy training to scientists in Africa

The program, funded by the Gates Foundation, will include both remote and immersive in-person training on cryogenic electron microscopy to study HIV and other infectious diseases

chemh.stanford.edu
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Institute Scholar @StevenMBanik, Melissa Gray & team built a new high-throughput tool to detect tiny changes in cellular protein levels, which could hopefully accelerate discovery of degrader drugs that fight diseases like cancer: news.stanford.edu/stories/20…
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Sarafan ChEM-H retweeted
Stanford Chemistry@StanfordUChem
Sep 9
Congrats to Laura Dassama, recipient of the @ASBMB Walter A. Shaw Young Investigator Award in Lipid Research! Her discoveries in bacterial lipid transport and metabolism are advancing research on host-pathogen interactions and anti-infective therapies. #StanfordChem #SarafanChEMH
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Congratulations to our Institute Scholar Laura Dassama on being awarded the 2027 @ASBMB Walter A. Shaw Young Investigator Award in Lipid Research, recognizing her outstanding research contributions in the area of lipids: brnw.ch/21x5yXP
Congratulations to our Institute Scholar Laura Dassama on being awarded the 2027 ASBMB Walter A. Shaw Young Investigator Award in Lipid Research.

ALT Congratulations to our Institute Scholar Laura Dassama on being awarded the 2027 ASBMB Walter A. Shaw Young Investigator Award in Lipid Research.
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