The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.
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September issue is now live!
Take a journey through our latest issue with insights into MTb susceptibility & containment, probiotics improving endometrial receptivity, oral commensal nanovaccines stimulating anti-tumor immunity & more……
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Cell Host & Microbe retweeted
Dietary pectin drives B. uniformis remodeling to enrich surface glycosphingolipid HexCer, while neutrophils sense the signal to promote IgA production, helping the bacterium colonize the gut & protects against colitis
Read more via @cellhostmicrobe :
tinyurl.com/4b9c2tr6
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Rewiring tryptophan metabolism for cancer immunotherapy
Oral nanoplatform releases tryptophan & metabolism inhibitor. Redirects tryptophan toward immunostimulatory microbial indole pathway, blocks immunosuppressive kynurenine & elicits antitumor immunity
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How Crops Turn the Tables on Fungal Toxins
Fusarium mycotoxin DON hijacks NAD+dependent enzymes to promote disease. However, crops use MIPS to redirect myo-inositol metabolism & drive DON sequestration, conferring resistance
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Weekend read! Female urogenital microbiome
Sarah Lebeer & Co
In urogenital tract, dominant lactobacilli shape vaginal immunity & community stability. Review examines molecular strategies & rational design of next-generation microbiome-based therapies
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Cell Host & Microbe retweeted
Could a sugar molecule produced by a gut bacterium offer a viable alternative to GLP-1s? A new paper in @cellhostmicrobe sheds light on a previously unknown link between the gut microbiome and metabolism.
Neeraj Surana, MD, PhD, and colleagues identified a previously unknown connection between the gut microbiome and metabolism.
Their findings suggest a naturally occurring gut bacterium may help regulate energy expenditure and visceral fat.
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One year ago--Veillonella promotes C. diff
Oral commensal Veillonella promotes C. difficile germination by disrupting bile acid recycling. Veillonella LPS activates signaling to suppress BA transporter, preventing bile acid reabsorption
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Commensal-derived sugar protects against obesity
Clostridium immunis & its bioactive phosphocholine-modified exopolysaccharide (EPS) reduces visceral adiposity & weight gain. By decreasing IL-22 levels, EPS increases metabolic activity in visceral fat
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Cell Host & Microbe retweeted
A commensal-derived sugar protects against obesity by regulating immunometabolism.
Learn more in Cell Host & Microbe: cell.com/cell-host-microbe/f…
Neeraj K. Surana & colleagues
@cellhostmicrobe
ALT graphical abstract
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Weekend revisit! E. faecalis lactic acid suppresses macrophages
E. faecalis-derived lactic acid suppresses macrophage NF-κB activation via MCT-1 & GPR81. This lactic-acid-driven immunosuppression promotes bacterial persistence & polymicrobial infection
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Diet drives Bacteroides remodeling to promote IgA binding
Pectin drives B. uniformis remodeling to enrich surface glycosphingolipid HexCer. Neutrophils sense signal to promote IgA production, which helps bacterium colonize gut & protects against colitis
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Timely revisit! Abs power MMR efficacy against measles
Measles-specific mAbs isolated from MMR vaccinee potently & broadly neutralize, target conserved sites & protect animals post exposure, opening means to prevent/treat measles as outbreaks re-emerge
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Microbial IAM alleviates PCOS
C. aerofaciens & metabolite indole-3-acetamide (IAM) mitigate polycystic ovary syndrome pathology via activating adipose HIF-2α-ceramide signaling. Probiotic strain producing IAM shows therapeutic efficacy in mouse PCOS model
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Rice circadian clock coordinates rhizosphere to optimize N acquisition
Clock component Nhd1 drives rhythmic root exudation to regulate microbial Nitrogen turnover. SynC microbes matching rice Nhd1 rhythm enhance grain yield & N use efficacy
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Bacteria promote CaOx stones
C. glucuronolyticum-like bacteria enriched in urine of calcium oxalate stone patients & promote CaOx crystallization via hippuric acid degradation & biofilm formation. Hippuric acid prevents bacteria-driven crystallization
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Oral commensal nanovaccines for tumor control
Bacteria-based oral biohybrid vaccine induces mucosal immunity & drives a mucosa-periphery-tumor immune cascade. Combined w/PD-1 blockade, enhances immune cell trafficking, remodels distal TME & tumor control
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Pulling the strings: Endobacteria manipulate fungal mycotoxin production
Preview of work taking a comprehensive look at an endofungal bacterium, identifying a mechanism to change plant disease outcomes through antagonism of beneficial soil microbes.
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Endosymbionts boost fungi by disrupting rhizobiome
Bacterial endosymbionts stimulate Fusarium wilt to produce cyclic hexadepsipeptide beauvericin, which inhibits disease-suppressive rhizobacteria, thereby weakening microbiome-mediated suppression
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Plant cell-type-specific immune activation
Plant immunity is organized across leaf tissues through specialized cell-type programs. While a shared core program is broadly activated, individual cell types deploy distinct defenses that restrict pathogens
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Holding the granuloma together: Fibroblasts contain mycobacterial infection
Preview of work identifying LTA4H-dependent fibroblasts at the granuloma periphery that regulate eicosanoid signaling, thereby limiting mycobacterial dissemination
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Eicosanoids-Fibroblasts contain MTb
TB susceptibility gene lta4h contributes to recruitment & differentiation of fibroblasts that populate periphery of mycobacterial granulomas. These eicosanoid-regulated fibroblasts help contain infection in granuloma
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