eLife - the journal@eLife

The funder-researcher collaboration and open-access journal for research in the life and biomedical sciences | @eLifeCommunity

 Cambridge, UK
elifesciences.org
Joined September 2011
10,990 Photos and videos
Preserved cerebellar functions despite structural degeneration in older adults elifesciences.org/articles/1…

Preserved cerebellar functions despite structural degeneration in older adults

Cerebellar-dependent functions are mostly maintained or even enhanced across the lifespan, with cerebellar-mediated motor abilities remaining intact despite degeneration, in contrast to non-cerebel...

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Polo-like kinase phosphorylation of the orphan kinesin KIN-G negatively regulates centrin arm biogenesis in <i>Trypanosoma brucei</i> elifesciences.org/articles/1…

Polo-like kinase phosphorylation of the orphan kinesin KIN-G negatively regulates centrin arm...

Polo-like kinase phosphorylation of the centrin arm-localized orphan kinesin KIN-G disrupts its microtubule-binding activity and inhibits centrin arm biogenesis in trypanosomes.

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Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex elifesciences.org/articles/1…

Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex

Multimodal data-driven computational modeling reveals that realistic cortical connectivity can generate more macroscopic traveling waves than local or uniform connectivity in the mouse cortex.

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Soil extracellular DNA fragments show variable degradation rates among sequences and environmental conditions elifesciences.org/articles/1…

Soil extracellular DNA fragments show variable degradation rates among sequences and environmental...

Extracellular DNA degrades at markedly different rates across soils and sequences, substantially biasing estimates of prokaryotic abundance, diversity, and community composition.

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Looking for a home for your microbiology paper? We aim to publish research in Microbiology and Infectious Disease, including microbiomes, microbial ecology, mycology, pathology, parasitology, and virology. Take a look at what we publish ⬇️ elifesciences.org/subjects/m…
Stylized illustration of assorted microbes—rod-shaped bacteria with hair-like appendages, round cocci in short chains, and spiky virus-like particles—scattered across a teal background to represent germs and microorganisms.

ALT Stylized illustration of assorted microbes—rod-shaped bacteria with hair-like appendages, round cocci in short chains, and spiky virus-like particles—scattered across a teal background to represent germs and microorganisms.
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Differential locus coeruleus–hippocampus interactions during offline states elifesciences.org/articles/1…

Differential locus coeruleus–hippocampus interactions during offline states

Noradrenergic tone varies with arousal state, is inversely correlated with hippocampal ripple and sleep spindle oscillations, and differs according to ripple–spindle coupling, with potential implic...

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The insulin/IGF axis is critically important for controlling gene transcription in the podocyte elifesciences.org/articles/1…

The insulin/IGF axis is critically important for controlling gene transcription in the podocyte

Simultaneously knocking down both the insulin and IGF1 receptor in the kidney podocyte is highly detrimental, affecting spliceosome function and gene transcription.

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Squidly harnesses enzyme functional hierarchy and contrastive learning to efficiently predict catalytic residues from sequence elifesciences.org/articles/1…

Squidly harnesses enzyme functional hierarchy and contrastive learning to efficiently predict...

Squidly enables efficient identification of enzyme catalytic residues by integrating functional hierarchies into a contrastive learning framework, requiring only protein sequences to produce scalable...

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Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA elifesciences.org/articles/1…

Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA

The ribosomal rRNA methyltransferase GidB is involved in the discrimination of mischarged tRNAs in mycobacteria.

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Low-frequency tibial neuromodulation excites bladder activity in humans elifesciences.org/articles/1…

Low-frequency tibial neuromodulation excites bladder activity in humans

Computational modeling and human pilot study present a mechanistic framework explaining the capacity for transcutaneous tibial nerve stimulation to induce excitatory or inhibitory effects based on...

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A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases elifesciences.org/articles/1…

A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

Evolutionarily unrelated microtubule and actin regulatory factors use the same mechanism to accelerate polymerization.

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How much does our environment shape not just our own health, but the generations that follow? Our latest collection highlights research on the mechanisms and biological significance of environmentally driven epigenetic inheritance 🧬 Explore it here ⬇️ elifesciences.org/collection…

Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

eLife publishes research on the mechanisms and biological significance of environmentally driven epigenetic inheritance.

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Do you have a paper that would be a great fit for this collection? Find out how you can Own Your Impact by publishing research with eLife: elifesciences.org/about/own-…

eLife | Own Your Impact · eLife

Be part of improving how research is communicated.

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Complementary vertebrate <i>Wac</i> models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome elifesciences.org/articles/1…

Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

Two distinct vertebrate models were generated and phenotyped to study DESSH syndrome caused by the Wac gene.

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Bring your research to life with an author explainer video. Whether you're talking through your figures or summarising your research, explainer videos can make your work more accessible and engaging. Our tips will help you create yours. elifesciences.org/inside-eli…

Author explainer videos: Top tips for creating your videos

Our author explainer videos allow you to illustrate your research and figures, bringing them to life, but what makes a good explainer video? Read our top tips.

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<i>In extracto</i> cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles elifesciences.org/articles/1…

In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

Cryogenic electron microscopy of cellular extracts can visualize atomic details and discover new interactions between biological molecules, such as the interactions of the ribosome, the protein-mak...

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Sensitivity of the human temporal voice areas to nonhuman primate vocalizations elifesciences.org/articles/1…

Sensitivity of the human temporal voice areas to nonhuman primate vocalizations

Vocalizations of nonhuman primates, especially when acoustic and phylogenetic proximity is the highest, enhance human brain activity in the anterior temporal lobe.

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Frequency and laminar profile of feature-specific visual activity revealed by interleaved EEG–fMRI elifesciences.org/articles/1…

Frequency and laminar profile of feature-specific visual activity revealed by interleaved EEG–fMRI

Combined human laminar EEG–fMRI reveals feature-specific gamma band activity, and dissociates general (lower frequency) from feature-specific (higher frequency) alpha band activity related to...

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Brain cognition gaps reveal associations with dopamine and factors related to brain health through artificial intelligence prediction of functional connectome elifesciences.org/articles/1…

Brain cognition gaps reveal associations with dopamine and factors related to brain health through...

Artificial intelligence and multimodal neuroimaging revealed brain state-dependent differences in the functional connectivity prediction of memory and identified the dopamine-modulated brain cognit...

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Mesoscale functional architecture in medial posterior parietal cortex elifesciences.org/articles/1…

Mesoscale functional architecture in medial posterior parietal cortex

Medial PPC comprises two specialized modules, with AM integrating visual and choice signals and A representing choice history and posture.

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